Two-stage design for time-to-event-endpoints

When conducting a study with time-to-event endpoints, the main interest is not the sample size, but the number of overall necessary events. Thus, adoptr does not use the sample size for calculating the design. Instead, it uses the number of events directly. In the framework of adoptr, all the calculations are done group-wise, where both of the groups are equal-sized. This means, that the number of events adoptr has computed is only half of the overall number of necessary events. In order to facilitate this issue, the look of the summary and show functions have been changed in the survival analysis setting. The sample size is implicitly determined by dividing the number of events by the event rate. Survival objects are only created, when the argument event_rate is not missing.

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event_rate: probability that a subject in either group will eventually have an event

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See also